The Need for a Personalized Treatment
Treating patients with TBI can be difficult because each injury is different in size, shape, spread and location. Penetrating injuries generate mechanical damage to brain tissue. Non-penetrating injuries inflict widespread neuronal disruption.
We believe that, to repair TBIs, each injured site must receive a continuous flow of neuro-protective and neuro-regenerative agents. These agents will prevent further neuronal damage and have the potential to stimulate neurons to migrate to the injury site, regrow axonal processes and regenerate brain tissue.
Genetically modified mesenchymal stem cells (MSCs) offer a unique potential mechanism to secrete these agents to continuously and safely drive TBI repair mechanisms.
A New Scientific Era
Chemistry and molecular biology are making major advances.
In molecular biology, gene editing technologies, such as CRISPR-Cas9, are making DNA manipulation easier and more accurate. In chemistry, advanced smart materials, with unique traits, are offering new ways to solve age-old problems. The intersection between these distinct disciplines offers incredible opportunities to develop new treatments. Our research teams are harnessing these new capabilities to develop a novel treatment for TBI.
Solving TBI, Helping Patients
At Qrons, we are taking a multi-disciplinary approach to a highly complex condition. Our solution integrates a 3D-printable, customized scaffold with innovative, engineered MSCs that target brain injuries and with the goal of regenerating damaged tissue.
3D Scaffold
Made from advanced smart materials, our 3D printable scaffold is designed to address the procedural, mechanical and personalized delivery challenges associated with TBI treatment.
Engineered MSC
Our proprietary, engineered mesenchymal stem cells act like living pharmacies, continuously delivering neuro-protective and neuro-regenerative agents to affected areas. We believe this combination will minimize neuronal loss and ultimately help patients regain or improve function.
Delivery System
The Qrons treatment is designed to integrate into existing surgical workflows. TBI patients often undergo cranial surgery to clean the injury site, stop bleeding or alleviate intracranial pressure. This offers a unique opportunity to deliver our novel, cell-based system.
A Uniquely Collaborative Approach
Advancing any complex technology requires multiple teams with different scientific and engineering skills.
Qrons has adopted a multidisciplinary, multi-team approach. Each has different skills, covering basic materials, 3D printing, molecular biology and software. In this way, Qrons has taken cues from high-tech companies: create groups that solve pieces of a larger problem and coordinate closely to deliver products.
The company is collaborating with basic and translational researchers at Ariel University and Dartmouth College.