About Traumatic Brain Injury
Traumatic brain injuries (TBIs) are a severe form of neuronal damage caused by powerful head impacts. Patients can experience transient symptoms, profound disability or death. TBI is generally caused by violent acts, motor vehicle accidents, falls and sports-related concussions.
The Widespread Impact of TBI
TBI is the number one cause of death among young adults.
In the U.S., there are more than two million brain injuries each year and approximately 50,000 people die from these injuries. The direct and indirect medical costs exceed $76 billion annually. In addition, TBI exacts heavy tolls on the medical system and caregivers.
TBI can be caused by penetrating injuries, in which an object pierces the skull and directly damages the brain, or non-penetrating blows that push the brain against the skull, inflicting neuronal damage.
Concept of Diffuse Axonal Injury (DAI)
Most TBI cases are caused by a non-penetrating blow that pushes the brain against the skull, inducing widespread neuronal death. TBI can also be caused by a penetrating injury, in which an object pierces the skull and directly damages the brain.
Penetrating injuries generate around 10 percent of TBIs.
What TBI Does to the Brain
Neuronal cells interconnect to create the gigantic network that drives core brain functions.
Unfortunately, neurons rarely regenerate after an injury. As a result, following a severe brain injury, neural connectivity is lost and brain function compromised.
TBI patients can become blind, deaf, paralyzed and experience cognitive and psychological issues. There is also evidence that TBI patients are more likely to develop Alzheimer’s, Huntington’s, Parkinson’s and other neurodegenerative diseases.
The Unmet Medical Need
There are no effective treatments to help patients regain function.
Current treatments focus on reducing secondary injuries. They can partially reduce further damage but do little or nothing to heal the brain. Most strategies are rehabilitative, helping patients adjust to their impaired cognitive state by creating workarounds, such as taking notes to compensate for lost short-term memory.
Qrons Approach to TBI